Virtual glioblastoma: growth, migration and treatment in a three-dimensional mathematical model

Virtual glioblastoma: growth, migration and treatment in a three-dimensional mathematical model.

OBJECTIVES Glioblastomas are aggressive primary brain cancers that are characterized by extensive infiltration into the brain and are highly resistant to treatment. Through mathematical modelling, we model the process of invasion and predict the relative importance of mechanisms contributing to malignant invasion. Clinically, we predict patterns of tumour recurrence following various modes of t...

A Mathematical Model of Collective Cell Migration in a Three-Dimensional, Heterogeneous Environment

Cell migration is essential in animal development, homeostasis, and disease progression, but many questions remain unanswered about how this process is controlled. While many kinds of individual cell movements have been characterized, less effort has been directed towards understanding how clusters of cells migrate collectively through heterogeneous, cellular environments. To explore this, we h...

P105: Inhibition of Vasculogenic Mimicry in a Three-Dimensional Culture in Glioblastoma

Glioblastoma is one of the most common primary brain tumors (80% of patients) that has a poor prognosis due to malignancy. Glioblastoma has an annual incidence of 5.26 per 100 000 population or 17 000 new diagnoses per year and so as the population aging, the number of patients is expected to increase. There is a growing body of literature investigating the tumor microenvironmenta...

Low Doses of Celecoxib Stimulate Human Endometrium Growth in A Three-Dimensional Culture Model

A three-dimensional mathematical model for drug delivery from drug-eluting stents

Current drug-eluting stent (DES) technology is not optimized with regard to the pharmacokinetics of drug release, more research on the <span style="font-size: 12pt; color: #000000; font-style: normal; ...